Postdoctoral Research Associate

Job ID 2018_05: Postdoctoral Research Associate

Date Posted: October 25, 2018

Company Summary:
Adecto Pharmaceuticals is an early-stage cancer therapeutics company focused on developing an antibody-based targeted therapy against cancers that express the cell surface protein ADAM8. The ADAM8 protein is a critical driver of tumor growth and spread and has been implicated in a number of aggressive cancers including breast, liver, gastric, lung and pancreatic. Our initial focus is on triple-negative breast cancer but we plan on expanding to other oncology indications in the future. Adecto's technology is based on the discovery that two distinct extracellular portions of ADAM8 drive its multiple cancer promoting functions and must therefore be both inactivated for an effective therapeutic response. Using a proprietary method, Adecto has generated highly specific dual antagonist monoclonal anti-ADAM8 antibodies that simultaneously inhibit these two domains. Our top two dual inhibitors, termed ADPs, are currently advancing through preclinical development. Adecto’s mission is to bring this new therapy to patients with ADAM8-positive disease to help them live longer, healthy lives.

Role / Responsibilities:
Adecto Pharmaceuticals is currently seeking an outstanding postdoctoral research associate to join its growing team. The full-time role will utilize mouse models of breast cancer, and cell-based and molecular assays to study the mechanisms of ADP action either as monotherapies or in combination with various standard-of-care treatments or other experimental therapies. The successful candidate will directly contribute to the development of a new therapy with a potential to have high impact on patient lives. This position will be located in Boston, MA.

Required qualifications:

- PhD in immunology, immuno-oncology, cancer biology, biochemistry, cell biology or related discipline, within 1-3 years of graduation

- Substantial experience with cellular immunology and/or cancer mouse models

- Experience with aseptic mammalian cell culture (e.g., stable and transient transfections) and cell-based assays (e.g., migration, invasion, FACS, effector function assays, immunofluorescence)

- Experience with molecular assays (e.g., qPCR, Western blot analysis, ELISA)

- Demonstrated excellence in planning, executing, and analyzing experiments

- Ability to troubleshoot and develop improvements

- Attention to detail and careful record-keeping

- Ability to work independently and as part of a team

- Ability to summarize and present results

- Strong publication record

- Proficiency with Microsoft Office (Powerpoint, Excel, Word, etc.) programs

- Authorized to legally work in the U.S.

Preferred qualifications:

- Experience with biologics is preferred

- Experience with immunohistochemistry or high-throughput assays is a plus

Personal characteristics:

- Highly self-motivated and goal-oriented, able to accomplish goals with minimal oversight

- Excellent organizational skills and ability to manage multiple projects

- Excellent interpersonal skills, flexible team player excited to collaborate with internal and external partners

- Excellent oral and written communication skills, able to write technical reports and protocols

Job Type: Full-time

To be considered for this position, please use the following fields to upload a cover letter and resume, and click submit.

Adecto Pharmaceuticals Inc. is an Equal Opportunity Employer. M/F/V/D.